Replication Data for: Quality control of cervical cytology using a 3-type HPV mRNA test increases screening program sensitivity of cervical intraepithelial neoplasia grade 2+ in young Norwegian women – a cohort study (doi:10.18710/TDJV8X)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Document Description

Citation

Title:

Replication Data for: Quality control of cervical cytology using a 3-type HPV mRNA test increases screening program sensitivity of cervical intraepithelial neoplasia grade 2+ in young Norwegian women – a cohort study

Identification Number:

doi:10.18710/TDJV8X

Distributor:

DataverseNO

Date of Distribution:

2019-11-15

Version:

1

Bibliographic Citation:

Skjeldestad, Finn Egil, 2019, "Replication Data for: Quality control of cervical cytology using a 3-type HPV mRNA test increases screening program sensitivity of cervical intraepithelial neoplasia grade 2+ in young Norwegian women – a cohort study", https://doi.org/10.18710/TDJV8X, DataverseNO, V1, UNF:6:M7dRklbtWaDqpYHrG432PA== [fileUNF]

Study Description

Citation

Title:

Replication Data for: Quality control of cervical cytology using a 3-type HPV mRNA test increases screening program sensitivity of cervical intraepithelial neoplasia grade 2+ in young Norwegian women – a cohort study

Identification Number:

doi:10.18710/TDJV8X

Authoring Entity:

Skjeldestad, Finn Egil (UiT The Arctic University of Norway)

Producer:

UiT The Arctic University of Norway

Date of Production:

2019-11-05

Distributor:

DataverseNO

Distributor:

UiT The Arctic University of Norway

Access Authority:

Skjeldestad, Finn Egil

Depositor:

Skjeldestad, Finn Egil

Date of Deposit:

2019-11-13

Holdings Information:

https://doi.org/10.18710/TDJV8X

Study Scope

Keywords:

Medicine, Health and Life Sciences, Cervical cytology, Cervical cancer, Screening, Cytology, mRNA, HPV genotypes, Validation

Abstract:

The dataset comprise the variables necessary to replicate the results published.

</P>Abstract: Within 2021, Norway intends to complete implementation of HPV DNA-based primary screening for cervical cancer for women 34-69 years, while continue cytology-based screening for women 25-33 years. Over the recent years, the incidence of cervical cancer has increased by 30% among women younger than 40 years. In this subset of women, nearly 30% were diagnosed with a normal smear, as most recent smear, prior the cancer diagnosis. This observation demands quality control of normal smears. The aim of this study was to assess increase in program sensitivity of CIN2+ after follow-up of women with false negative Pap-smears testing positive for a 3-type (-16, -18, -45) HPV mRNA test in a cohort design over one screening interval. 521 women, aged 23-39 years, and no prior history of CIN1+ or HSIL, with an ASC-US or worse smear (ASC-US+) and 1444 women with normal screening cytology comprised the study cohorts. The positivity rate for the 3-type HPV mRNA was 1.9% (28/1444). Rescreening revealed 23 women with ASC-US, two women with LSIL, two women with ASC-H, and one woman with AGUS. If the HPV mRNA-positivity rate and histology findings from samples rescreened were applied to all women with normal cytology, an estimated increase in screening sensitivity of 16.4% (95% CI:15.3 -17.5) for CIN2+ and 17.3% (95% CI:16.2-18.4) for CIN3+ were achieved. By rescreening less than 2% of women with normal cytology positive for a 3-type HPV mRNA test, we achieved a significant increase in screening program sensitivity.

Methodology and Processing

Sources Statement

Data Access

Other Study Description Materials

Related Publications

Citation

Title:

Westre B, Giske A, Guttormsen H, Wergeland Sørbye S, Skjeldestad FE (2019) Quality control of cervical cytology using a 3-type HPV mRNA test increases screening program sensitivity of cervical intraepithelial neoplasia grade 2+ in young Norwegian women—A cohort study.

Identification Number:

10.1371/journal.pone.0221546

Bibliographic Citation:

Westre B, Giske A, Guttormsen H, Wergeland Sørbye S, Skjeldestad FE (2019) Quality control of cervical cytology using a 3-type HPV mRNA test increases screening program sensitivity of cervical intraepithelial neoplasia grade 2+ in young Norwegian women—A cohort study.

File Description--f10371

File: Quality_control_cervical_cytology.tab

  • Number of cases: 4366

  • No. of variables per record: 11

  • Type of File: text/tab-separated-values

Notes:

UNF:6:M7dRklbtWaDqpYHrG432PA==

Variable Description

List of Variables:

Variables

Continuous

f10371 Location:

Summary Statistics: StDev 4.689661459401187; Mean 31.366010077874456; Min. 23.0; Max. 39.0; Valid 4366.0;

Variable Format: numeric

Notes: UNF:6:1CRPNEEjSVkDAgpo1atvwA==

Prim scr

f10371 Location:

Value

Label

Frequency

Text

3.

ASCUS LSIL

452

1.

Norm cyt - SEE

2401

2.

Norm cyt SEE

1444

4.

HSIL

69

Summary Statistics: StDev 0.7380672212212869; Min. 1.0; Mean 1.585203847915728; Valid 4366.0; Max. 4.0

Variable Format: numeric

Notes: UNF:6:LX8I7X847Tzeb2bsDROK6Q==

Rescreening

f10371 Location:

Value

Label

Frequency

Text

4.

ASCU, LSIL

452

2.

Norm, see neg

1416

3.

Norm, see pos

28

5.

HSIL

69

1.

Norm, See (-)

2401

Summary Statistics: Min. 1.0; StDev 1.0145806072193366; Valid 4366.0; Max. 5.0; Mean 1.7109482363719886;

Variable Format: numeric

Notes: UNF:6:BLb8FkKOlODCK4QCatnlRA==

Primary cytology

f10371 Location:

Value

Label

Frequency

Text

6.

ACIS

1

-1.

Unsat

2

7.

Sq CC

0

5.

AGUS

1

1.

ASC-US

370

4.

ASC-H

32

9.

ca usp

0

3.

HSIL

35

2.

LSIL

82

11.

metast

0

0.

Norm

3843

8.

adeno ca

0

Summary Statistics: Mean 0.17773705909298382; Max. 6.0; Valid 4366.0; Min. -1.0; StDev 0.5763725174239817

Variable Format: numeric

Notes: UNF:6:sSBx/4t8IDWbbLWVqJH8dQ==

Cytology rescre SEE pos

f10371 Location:

Value

Label

Frequency

Text

4.

ASC-H

34

11.

metast

0

8.

adeno ca

0

-1.

Uegnet

2

3.

HSIL

35

5.

AGUS

2

2.

LSIL

83

0.

Norm

3815

1.

ASC-US

394

6.

ACIS

1

9.

ca usp

0

7.

Sq CC

0

Summary Statistics: Mean 0.18666972056801923; Max. 6.0; StDev 0.5902732350665938; Min. -1.0; Valid 4366.0

Variable Format: numeric

Notes: UNF:6:AoUY8HMEjM4RsCZqigi2bA==

SEE positivity

f10371 Location:

Summary Statistics: Max. 1.0; Min. -1.0; Mean -0.5950526797984481; Valid 4366.0; StDev 0.5377082457901851;

Variable Format: numeric

Notes: UNF:6:1OVJPPx2tAEE5d/WyFohRA==

HPV 16

f10371 Location:

Summary Statistics: Mean 0.04028863499699461; StDev 0.19669449739118747; Max. 1.0; Valid 1663.0; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:oHvX+LRghwOCpBapve0TEQ==

HPV 18

f10371 Location:

Summary Statistics: Min. 0.0; Mean 0.022248947684906494; StDev 0.14753650741511995; Valid 1663.0; Max. 1.0

Variable Format: numeric

Notes: UNF:6:yHmZwGUs5ZNKb8ddhF+I0Q==

HPV 45

f10371 Location:

Summary Statistics: Mean 0.004810583283222933; Valid 1663.0; Min. 0.0; Max. 1.0; StDev 0.06921215284996186

Variable Format: numeric

Notes: UNF:6:9pBWLSor/m+dKS+Mv2LZog==

Indication biopsy

f10371 Location:

Summary Statistics: Min. 0.0; Valid 4366.0; Max. 1.0; StDev 0.2798962485791501; Mean 0.08566193311956444;

Variable Format: numeric

Notes: UNF:6:8RQryfZXkggJD2L85prqYA==

Status end of study

f10371 Location:

Value

Label

Frequency

Text

21.

CIN 1

47

0.

Back to scr

2751

26.

ACIS

9

28.

adeno cc

1

25.

AGUS

2

-1.

no attend

1163

23.

CIN 3

144

20.

Normal biop

60

4.

incompl f-up

158

27.

Sq cc

3

22.

CIN 2

28

Summary Statistics: StDev 5.668759688768801; Valid 4366.0; Max. 28.0; Min. -1.0; Mean 1.3689876316995664

Variable Format: numeric

Notes: UNF:6:axUuBmMRyeXz8Ee96g0mYg==

Other Study-Related Materials

Label:

00_ReadMe.pdf

Notes:

application/pdf