10.18710/GNTWOGLanger, Manuel KarlManuel KarlLanger0000-0002-6174-7381UiT The Arctic University of NorwayZilioli, FrancescoFrancescoZilioliUiT The Arctic University of NorwayBayer, AnnetteAnnetteBayer0000-0003-3481-200XUiT The Arctic University of NorwayReplication Data for: A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profileDataverseNO2022ChemistryMedicine, Health and Life SciencesAntimicrobial peptides (AMPs)Amphipathic, Tetrasubstituted BarbituratesSmall mimics of antimicrobial peptides (SMAMPs)Nuclear magnetic resonance (NMR)High resolution mass spectrometry (HRMS)Infrafred spectroscopy (IR)Supercritical fluid chromatography (SFC)Langer, Manuel KarlManuel KarlLangerUiT The Arctic University of NorwayUiT The Arctic University of NorwayJohansen, JosteinJosteinJohansenBayer, AnnetteAnnetteBayerUiT The Arctic University of NorwayUiT The Arctic University of Norway2022-04-302022-05-162023-09-282018-07-01/2021-08-03Experimental Data1170342485715324630249328152806102892300text/plainapplication/pdfapplication/pdftext/comma-separated-valuestext/csvtext/plainapplication/zip2.1CC0 1.0<p>This dataset contains the analytical data of 58 amphipathic, tetrasubstituted barbituric acid derivatives and their synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files.</p> <p>The barbituric acid derivatives were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile". The structure of all compounds can be found in the data files.</p>MassLynx, V4.1LTQ Tune Plus, V2.5.5 SP2Qual Browser Thermo Xcalibur, 2.1.0 SP1.1160Icon NMR for TopSpin 3.2, 4.7.6 Build 22UiT The Arctic University of NorwayUiT The Arctic University of NorwayAntifoMarUiT The Arctic University of NorwayLeadScAMR