Replication Data for: A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profiledoi:10.18710/GNTWOGDataverseNO2022-07-132Langer, Manuel Karl; Zilioli, Francesco; Bayer, Annette, 2022, "Replication Data for: A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile", https://doi.org/10.18710/GNTWOG, DataverseNO, V2Replication Data for: A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profiledoi:10.18710/GNTWOGLanger, Manuel KarlZilioli, FrancescoBayer, AnnetteJohansen, JosteinBayer, AnnetteUiT The Arctic University of Norway2022-04-30UiT The Arctic University of NorwayMassLynxLTQ Tune PlusQual Browser Thermo XcaliburIcon NMR for TopSpin 3.2AntifoMarLeadScAMRDataverseNOUiT The Arctic University of NorwayLanger, Manuel KarlLanger, Manuel K2022-05-16ChemistryMedicine, Health and Life SciencesAntimicrobial peptides (AMPs)Amphipathic, Tetrasubstituted BarbituratesSmall mimics of antimicrobial peptides (SMAMPs)Nuclear magnetic resonance (NMR)High resolution mass spectrometry (HRMS)Infrafred spectroscopy (IR)Supercritical fluid chromatography (SFC)<p>This dataset contains the analytical data of 58 amphipathic, tetrasubstituted barbituric acid derivatives and their synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files.</p> <p>The barbituric acid derivatives were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile". The structure of all compounds can be found in the data files.</p>2018-07-012021-08-03Experimental DataThe data is part of manuscript send for review. The editor and reviewers can contact the contactperson specified in the ReadMe file for access. When the manuscript is accepted the data is to become unrestricted.M.K. Langer, A. Rahman, H. Dey, T. Anderssen, F. Zilioli, T. Haug, H.-M. Blencke, K. Stensvåg, M.B. Strøm, A. Bayer, A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile, Eur. J. Med. Chem., 241 (2022) 114632.
https://doi.org/10.1016/j.ejmech.2022.114632M.K. Langer, A. Rahman, H. Dey, T. Anderssen, F. Zilioli, T. Haug, H.-M. Blencke, K. Stensvåg, M.B. Strøm, A. Bayer, A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile, Eur. J. Med. Chem., 241 (2022) 114632.
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