10.18710/A6AJN4Langer, Manuel KarlManuel KarlLanger0000-0002-6174-7381UiT The Arctic University of NorwayBayer, AnnetteAnnetteBayer0000-0003-3481-200XUiT The Arctic University of NorwayReplication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic PropertiesDataverseNO2022ChemistryMedicine, Health and Life SciencesAntimicrobial peptidesAMPsAmphipathic, Tetrasubstituted BarbituratesSmall mimics of antimicrobial peptidesSMAMPsNuclear magnetic resonanceNMRHigh resolution mass spectrometryHRMSInfrafred spectroscopyIRSupercritical fluid chromatographySFCLanger, Manuel KarlManuel KarlLangerUiT The Arctic University of NorwayUiT The Arctic University of NorwayLanger, Manuel KarlManuel KarlLangerJohansen, JosteinJosteinJohansenBayer, AnnetteAnnetteBayerUiT The Arctic University of NorwayUiT The Arctic University of Norway2022-05-222022-11-142023-09-282018-07-20/2022-04-04Analytical data14372488279121505182441859588569786348text/plainapplication/pdfapplication/pdftext/comma-separated-valuestext/csvtext/plainapplication/zip1.1CC0 1.0This dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files. All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files.MassLynx, V4.1LTQ Tune Plus, V2.5.5 SP2Qual Browser Thermo Xcalibur, 2.1.0 SP1.1160Icon NMR for TopSpin 3.2, 4.7.6 Build 22Thermo Scientific SII for Xcalibur, 1.6.060983Thermo Scientific FreeStyle, 1.8 SP2Thermo Scientific Xcalibur, 4.4.16.14TromsøUiT The Arctic University of NorwayUiT The Arctic University of Norway2017/6770