Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Propertiesdoi:10.18710/A6AJN4DataverseNO2022-11-171Langer, Manuel Karl; Bayer, Annette, 2022, "Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties", https://doi.org/10.18710/A6AJN4, DataverseNO, V1Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Propertiesdoi:10.18710/A6AJN4Langer, Manuel KarlBayer, AnnetteLanger, Manuel KarlJohansen, JosteinBayer, AnnetteUiT The Arctic University of Norway2022-05-22TromsøMassLynxLTQ Tune PlusQual Browser Thermo XcaliburIcon NMR for TopSpin 3.2Thermo Scientific SII for XcaliburThermo Scientific FreeStyleThermo Scientific Xcalibur2017/6770DataverseNOUiT The Arctic University of NorwayLanger, Manuel KarlLanger, Manuel K2022-11-14ChemistryMedicine, Health and Life SciencesAntimicrobial peptidesAMPsAmphipathic, Tetrasubstituted BarbituratesSmall mimics of antimicrobial peptidesSMAMPsNuclear magnetic resonanceNMRHigh resolution mass spectrometryHRMSInfrafred spectroscopyIRSupercritical fluid chromatographySFCThis dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files.
All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files.2018-07-202022-04-04Analytical dataSubmitted manuscriptSubmitted manuscript00_README_edit.txttext/plain01_Chemical_structures.pdfapplication/pdf02_Analytical_data_overview.pdfapplication/pdf03_Analytical_data_overview.csvtext/comma-separated-values04_SMILEs_all_structures.csvtext/csv05_file_tree.txttext/plainraw_data.zipapplication/zip