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Part 1: Document Description
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Citation |
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Title: |
Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties |
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Identification Number: |
doi:10.18710/A6AJN4 |
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Distributor: |
DataverseNO |
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Date of Distribution: |
2022-11-17 |
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Version: |
1 |
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Bibliographic Citation: |
Langer, Manuel Karl; Bayer, Annette, 2022, "Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties", https://doi.org/10.18710/A6AJN4, DataverseNO, V1 |
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Citation |
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Title: |
Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties |
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Identification Number: |
doi:10.18710/A6AJN4 |
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Authoring Entity: |
Langer, Manuel Karl (UiT The Arctic University of Norway) |
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Bayer, Annette (UiT The Arctic University of Norway) |
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Other identifications and acknowledgements: |
Langer, Manuel Karl |
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Other identifications and acknowledgements: |
Johansen, Jostein |
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Other identifications and acknowledgements: |
Bayer, Annette |
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Producer: |
UiT The Arctic University of Norway |
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Date of Production: |
2022-05-22 |
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Software used in Production: |
MassLynx |
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Software used in Production: |
LTQ Tune Plus |
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Software used in Production: |
Qual Browser Thermo Xcalibur |
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Software used in Production: |
Icon NMR for TopSpin 3.2 |
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Software used in Production: |
Thermo Scientific SII for Xcalibur |
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Software used in Production: |
Thermo Scientific FreeStyle |
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Software used in Production: |
Thermo Scientific Xcalibur |
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Grant Number: |
2017/6770 |
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Distributor: |
DataverseNO |
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Distributor: |
UiT The Arctic University of Norway |
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Access Authority: |
Langer, Manuel Karl |
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Depositor: |
Langer, Manuel K |
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Date of Deposit: |
2022-11-14 |
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Holdings Information: |
https://doi.org/10.18710/A6AJN4 |
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Study Scope |
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Keywords: |
Chemistry, Medicine, Health and Life Sciences, Antimicrobial peptides, AMPs, Amphipathic, Tetrasubstituted Barbiturates, Small mimics of antimicrobial peptides, SMAMPs, Nuclear magnetic resonance, NMR, High resolution mass spectrometry, HRMS, Infrafred spectroscopy, IR, Supercritical fluid chromatography, SFC |
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Abstract: |
This dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files. All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files. |
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Date of Collection: |
2018-07-20-2022-04-04 |
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Kind of Data: |
Analytical data |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Title: |
Submitted manuscript |
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Bibliographic Citation: |
Submitted manuscript |
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Label: |
00_README_edit.txt |
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Notes: |
text/plain |
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Label: |
01_Chemical_structures.pdf |
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Notes: |
application/pdf |
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Label: |
02_Analytical_data_overview.pdf |
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Notes: |
application/pdf |
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Label: |
03_Analytical_data_overview.csv |
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Notes: |
text/comma-separated-values |
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Label: |
04_SMILEs_all_structures.csv |
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Notes: |
text/csv |
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Label: |
05_file_tree.txt |
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Notes: |
text/plain |
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Label: |
raw_data.zip |
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Notes: |
application/zip |