10.18710/T5BQ22 Konst, Solveig Solveig Konst https://orcid.org/0009-0005-0798-9848 UiT The Arctic University of Norway Brun, Vegard Vegard Brun https://orcid.org/0000-0002-4136-3073 UiT The Arctic University of Norway Hellemo, Lars Lars Hellemo https://orcid.org/0000-0001-5958-9794 https://ror.org/01f677e56 DataverseNO 2026 Medicine, Health and Life Sciences Thyroidectomy Patient-centered medicine Levothyroxine Hypothyroidism Pharmacokinetic modeling UiT The Arctic University of Norway UiT The Arctic University of Norway Brun, Vegard Vegard Brun UiT The Arctic University of Norway Kaut, Michal Michal Kaut Eriksen, Brun Brun Eriksen Selseth, Ruth Ruth Selseth Johansson, Kenth Kenth Johansson Vik, Renate Renate Vik Davidsen, Benedicte Benedicte Davidsen 2026-02-23 2026-04-13 Clinical data 10.1089/THY.2021.0125 10.18710/T5BQ22/WGXEJW 10.18710/T5BQ22/RD2JQC 10.18710/T5BQ22/YKORLD 10.18710/T5BQ22/OI8DBV 10.18710/T5BQ22/N32RHQ 10.18710/T5BQ22/MEFYQO 10.18710/T5BQ22/LANRRU 99551 1987 5653 209531 115468 19303 8942 application/pdf text/plain text/plain application/pdf text/plain text/plain text/plain 1.0 Creative Commons CC0 1.0 Universal Public Domain Dedication. <p>This dataset constitutes the background data for the study: Patient-Tailored Levothyroxine Dosage with Pharmacokinetic/Pharmacodynamic Modeling: A Novel Approach After Total Thyroidectomy (doi: 10.1089/thy.2021.0125). The study's objective was to investigate whether a new pharmacokinetic/pharmacodynamic model for Levothyroxine dosage lead to better and faster levothyroxine dosage. Patients >18 years with a planned total thyroidectomy were eligible for participation.</p> <p>Data were collected in two phases. The first phase, conducted from 2016 to 2017, comprised the pilot study. Data from the pilot study was used to develop the pharmacokinetic/pharmacodynamic model.</p> <p>The second phase, conducted from 2017 to 2019, consisted of a randomised controlled trial utilizing the Pharmacokinetic/pharmacodynamic model for calculating each patient's optimal levothyroxine dosage.</p> <p>Data collected in the two phases are patient demographics, laboratory results and levothyroxine dosage. Laboratory results and levothyroxine dosage were collected at multiple time points during the study, both before and after surgery. Data from the pilot study and the RCT have been merged and anonymised.</p> <p>All participants provided written informed consent for data collection.</p> Norway Sweden Regional Research Funds North Norway 357035 Northern Norway Regional Health Authority HN1004-17