Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Propertieshttps://doi.org/10.18710/A6AJN4Langer, Manuel KarlBayer, AnnetteDataverseNO2022-11-172025-07-02T10:31:48ZThis dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files. All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files.ChemistryMedicine, Health and Life SciencesAntimicrobial peptidesAMPsAmphipathic, Tetrasubstituted BarbituratesSmall mimics of antimicrobial peptidesSMAMPsNuclear magnetic resonanceNMRHigh resolution mass spectrometryHRMSInfrafred spectroscopyIRSupercritical fluid chromatographySFCEnglishManuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Hans-Matti Blencke, Tor Haug, Klara Stensvåg, Morten B. Strøm, Annette Bayer, Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties, Eur. J. Med. Chem., 249 (2023) 115147., doi, 10.1016/j.ejmech.2023.115147, https://doi.org/10.1016/j.ejmech.2023.1151472022-05-22Langer, Manuel KLanger, Manuel KarlJohansen, JosteinBayer, Annette2022-11-142018-07-202022-04-04Analytical dataCC0 1.0