|
View: |
Part 1: Document Description
|
|
Citation |
|
|---|---|
|
Title: |
Background data for: Patient-Tailored Levothyroxine Dosage with Pharmacokinetic/Pharmacodynamic Modeling: A Novel Approach After Total Thyroidectomy |
|
Identification Number: |
doi:10.18710/T5BQ22 |
|
Distributor: |
DataverseNO |
|
Date of Distribution: |
2026-04-13 |
|
Version: |
1 |
|
Bibliographic Citation: |
Konst, Solveig; Brun, Vegard; Hellemo, Lars, 2026, "Background data for: Patient-Tailored Levothyroxine Dosage with Pharmacokinetic/Pharmacodynamic Modeling: A Novel Approach After Total Thyroidectomy", https://doi.org/10.18710/T5BQ22, DataverseNO, V1 |
|
Citation |
|
|
Title: |
Background data for: Patient-Tailored Levothyroxine Dosage with Pharmacokinetic/Pharmacodynamic Modeling: A Novel Approach After Total Thyroidectomy |
|
Identification Number: |
doi:10.18710/T5BQ22 |
|
Authoring Entity: |
Konst, Solveig (https://ror.org/00wge5k78) |
|
Brun, Vegard (https://ror.org/00wge5k78) |
|
|
Hellemo, Lars (https://ror.org/01f677e56) |
|
|
Other identifications and acknowledgements: |
Kaut, Michal |
|
Other identifications and acknowledgements: |
Eriksen, Brun |
|
Other identifications and acknowledgements: |
Selseth, Ruth |
|
Other identifications and acknowledgements: |
Johansson, Kenth |
|
Other identifications and acknowledgements: |
Vik, Renate |
|
Other identifications and acknowledgements: |
Davidsen, Benedicte |
|
Producer: |
UiT The Arctic University of Norway |
|
Grant Number: |
357035 |
|
Grant Number: |
HN1004-17 |
|
Distributor: |
DataverseNO |
|
Distributor: |
UiT The Arctic University of Norway |
|
Access Authority: |
Brun, Vegard |
|
Depositor: |
Konst, Solveig Robertsen |
|
Date of Deposit: |
2026-02-23 |
|
Holdings Information: |
https://doi.org/10.18710/T5BQ22 |
|
Study Scope |
|
|
Keywords: |
Medicine, Health and Life Sciences, Thyroidectomy, Patient-centered medicine, Levothyroxine, Hypothyroidism, Pharmacokinetic modeling |
|
Abstract: |
<p>This dataset constitutes the background data for the study: Patient-Tailored Levothyroxine Dosage with Pharmacokinetic/Pharmacodynamic Modeling: A Novel Approach After Total Thyroidectomy (doi: 10.1089/thy.2021.0125). The study's objective was to investigate whether a new pharmacokinetic/pharmacodynamic model for Levothyroxine dosage lead to better and faster levothyroxine dosage. Patients >18 years with a planned total thyroidectomy were eligible for participation.</p> <p>Data were collected in two phases. The first phase, conducted from 2016 to 2017, comprised the pilot study. Data from the pilot study was used to develop the pharmacokinetic/pharmacodynamic model.</p> <p>The second phase, conducted from 2017 to 2019, consisted of a randomised controlled trial utilizing the Pharmacokinetic/pharmacodynamic model for calculating each patient's optimal levothyroxine dosage.</p> <p>Data collected in the two phases are patient demographics, laboratory results and levothyroxine dosage. Laboratory results and levothyroxine dosage were collected at multiple time points during the study, both before and after surgery. Data from the pilot study and the RCT have been merged and anonymised.</p> <p>All participants provided written informed consent for data collection.</p> |
|
Date of Collection: |
2016-2019 |
|
Country: |
Norway, Sweden |
|
Kind of Data: |
Clinical data |
|
Methodology and Processing |
|
|
Sources Statement |
|
|
Data Sources: |
Data were collected directly from patients or from patients’ electronic health records. Anonymized data are reproduced here in accordance with approval by the Norwegian Regional Ethics Committee (2016/1782) and the Swedish Ethical Review Authority (443-17). |
|
Data Access |
|
|
Notes: |
<a href="http://creativecommons.org/publicdomain/zero/1.0">CC0 1.0</a> |
|
Other Study Description Materials |
|
|
Related Publications |
|
|
Citation |
|
|
Title: |
Brun VH, Eriksen AH, Selseth R, Johansson K, Vik R, Davidsen B, Kaut M, Hellemo L. Patient-Tailored Levothyroxine Dosage with Pharmacokinetic/Pharmacodynamic Modeling: A Novel Approach After Total Thyroidectomy. Thyroid. 2021 Sep;31(9):1297-1304. doi: 10.1089/thy.2021.0125. Epub 2021 Jun 22. PMID: 33980057; PMCID: PMC8558060. |
|
Identification Number: |
10.1089/thy.2021.0125 |
|
Bibliographic Citation: |
Brun VH, Eriksen AH, Selseth R, Johansson K, Vik R, Davidsen B, Kaut M, Hellemo L. Patient-Tailored Levothyroxine Dosage with Pharmacokinetic/Pharmacodynamic Modeling: A Novel Approach After Total Thyroidectomy. Thyroid. 2021 Sep;31(9):1297-1304. doi: 10.1089/thy.2021.0125. Epub 2021 Jun 22. PMID: 33980057; PMCID: PMC8558060. |
|
Label: |
00-readme.txt |
|
Notes: |
text/plain |
|
Label: |
consent-form.pdf |
|
Notes: |
application/pdf |
|
Label: |
data-privacy-assessment.pdf |
|
Text: |
Brief summary of the legal and ethical justification for publishing this dataset with open access. |
|
Notes: |
application/pdf |
|
Label: |
Lab-results.txt |
|
Notes: |
text/plain |
|
Label: |
Levothyroxine-Dosage.txt |
|
Notes: |
text/plain |
|
Label: |
Patient-demographic.txt |
|
Notes: |
text/plain |
|
Label: |
Thyrogen-Dosage.txt |
|
Notes: |
text/plain |