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Part 1: Document Description
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Citation |
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Title: |
Replication Data for: Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines |
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Identification Number: |
doi:10.18710/USXCRS |
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Distributor: |
DataverseNO |
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Date of Distribution: |
2019-05-06 |
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Version: |
1 |
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Bibliographic Citation: |
Konstantinell, Aelita Gloria Virginia, 2019, "Replication Data for: Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines", https://doi.org/10.18710/USXCRS, DataverseNO, V1, UNF:6:xGarNwkr+cO6GOAu/OngFQ== [fileUNF] |
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Citation |
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Title: |
Replication Data for: Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines |
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Identification Number: |
doi:10.18710/USXCRS |
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Authoring Entity: |
Konstantinell, Aelita Gloria Virginia (UiT The Arctic University of Norway) |
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Producer: |
UiT The Arctic University of Norway |
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Grant Number: |
2A65216 |
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Distributor: |
DataverseNO |
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Distributor: |
UiT The Arctic University of Norway |
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Access Authority: |
Konstantinell, Aelita Gloria Virginia |
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Depositor: |
Konstantinell, Aelita Gloria Virginia |
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Date of Deposit: |
2019-04-01 |
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Holdings Information: |
https://doi.org/10.18710/USXCRS |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Merkel cell carcinoma, Merkel cell polyomavirus, Exosome, Proteomics |
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Abstract: |
This dataset is about analyses of two Merkel cell polyomavirus (MCPyV)-negative and two MCPyV–positive Merkel cell lines secretomic proteins. |
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</p>Abstract: Extracellular vesicles or exosomes constitute an evolutionarily conserved mechanism of intercellular signaling. Exosomes are gaining an increasing amount of attention due to their role in pathologies, including malignancy, their importance as prognostic and diagnostic markers, and their potential as a therapeutic tool. Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a poor prognosis. Because an effective systemic treatment for this cancer type is currently not available, an exosome-based therapy was proposed. However, comprehensive secretome profiling has not been performed for MCC. To help unveil the putative contribution of exosomes in MCC, we studied the protein content of MCC-derived exosomes. Since approximately 80% of all MCC cases contain Merkel cell polyomavirus (MCPyV), the secretomes of two MCPyV-negative and two MCPyV-positive MCC cell lines were compared. We identified with high confidence 164 exosome-derived proteins common for all four cell lines that were annotated in ExoCarta and Vesiclepedia databases. These include proteins implicated in motility, metastasis and tumor progression, such as integrins and tetraspanins, intracellular signaling molecules, chaperones, proteasomal proteins, and translation factors. Additional virus-negative and virus-positiveMCC cell lines should be examined to identify highly representative exosomal proteins that may provide reliable prognostic and diagnostic biomarkers, as well as targets for treatment in the future. Data are available via ProteomeXchange with identifier PXD004198. |
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Date of Collection: |
2015-08-01-2015-12-31 |
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Kind of Data: |
Experimental data |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Notes: |
<a href="http://creativecommons.org/publicdomain/zero/1.0">CC0 1.0</a> |
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Other Study Description Materials |
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Related Studies |
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Biomarkers Discovery: The Benefit of the Study Exosomes Originated from Merkel Cell Carcinoma Cell Lines. doi: 10.18710/KCW912 |
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Related Publications |
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Citation |
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Title: |
A. Konstantinell, et al. Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines. Proteomics 2016, 16, 2587-2591. |
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Identification Number: |
10.1002/pmic.201600223 |
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Bibliographic Citation: |
A. Konstantinell, et al. Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines. Proteomics 2016, 16, 2587-2591. |
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File Description--f7602 |
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File: Supporting_Information_Table 2.tab |
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Notes: |
UNF:6:xGarNwkr+cO6GOAu/OngFQ== |
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List of Variables: |
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Variables |
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Table2.These37exosomalmarkersoftop100(www.exocarta.og)presentintwopolyomavirus-negativeandtwopolyomavirus-positiveMerkelcellcarcinomacelllines. |
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f7602 Location: |
Variable Format: character Notes: UNF:6:ARZyFm5kviD7nZuEQ8Px8g== |
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f7602 Location: |
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f7602 Location: |
Variable Format: character Notes: UNF:6:x2Utu3/K0Dh9apme+hwNAQ== |
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f7602 Location: |
Variable Format: character Notes: UNF:6:Rov6t2nr0qgw950wD+0wCA== |
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f7602 Location: |
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f7602 Location: |
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f7602 Location: |
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f7602 Location: |
Variable Format: character Notes: UNF:6:eS2/3PNRlCxjlPflsjLxjw== |
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Label: |
01_ReadMe.txt |
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Text: |
An overview and short description of the files contained in dataset, which icludes the contact information, what the dataset is about, column headings in tabular data, some abbreviations, and where to find which data = overview of files. |
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Notes: |
text/plain |
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Label: |
Supporting_Information_Table 1.txt |
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Notes: |
text/plain |
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Supporting_Information_Table 1.xlsx |
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application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Supporting_Information_Table 2.txt |
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text/plain |
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Supporting_Information_Table 3.txt |
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text/plain |
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Supporting_Information_Table 3.xlsx |
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application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Supporting_Information_Table 4.txt |
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text/plain |
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Supporting_Information_Table 4.xlsx |
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application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Supporting_Information_Table 5.txt |
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text/plain |
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Supporting_Information_Table 5.xlsx |
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application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Supporting_Information_Table 6.txt |
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text/plain |
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Label: |
Supporting_Information_Table 6.xlsx |
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Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |