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Part 1: Document Description
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Citation |
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Title: |
Replication data for: Human Foveal Cone and RPE Cell Topographies and Their Correspondence With Foveal Shape |
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Identification Number: |
doi:10.23642/USN.18134198 |
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Distributor: |
DataverseNO |
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Date of Distribution: |
2022-02-24 |
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Version: |
1 |
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Bibliographic Citation: |
Baraas Rigmor C.; Pedersen Hilde Røgeberg, 2022, "Replication data for: Human Foveal Cone and RPE Cell Topographies and Their Correspondence With Foveal Shape", https://doi.org/10.23642/USN.18134198, DataverseNO, V1 |
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Citation |
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Title: |
Replication data for: Human Foveal Cone and RPE Cell Topographies and Their Correspondence With Foveal Shape |
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Identification Number: |
doi:10.23642/USN.18134198 |
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Authoring Entity: |
Baraas Rigmor C. (University of South-Eastern Norway) |
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Pedersen Hilde Røgeberg (University of South-Eastern Norway) |
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Producer: |
University of South-Eastern Norway |
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Distributor: |
DataverseNO |
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Distributor: |
University of South-Eastern Norway |
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Access Authority: |
USN Research Data Support |
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Depositor: |
University of South-Eastern Norway |
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Date of Deposit: |
2022-02-24 |
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Holdings Information: |
https://doi.org/10.23642/USN.18134198 |
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Study Scope |
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Keywords: |
Other, cone densities, rpe densities, cone photoreceptors, retinal pigment epithelium, foveal shape |
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Abstract: |
DATASET MIGRATED FROM FIGSHARE: <div><div>Abstract</div><p>Purpose: To characterize the association between foveal shape and cone and retinal pigment epithelium (RPE) cell topographies in healthy humans.</p><p>Methods: Multimodal adaptive scanning light ophthalmoscopy and optical coherence tomography (OCT) were used to acquire images of foveal cones, RPE cells, and retinal layers in eyes of 23 healthy participants with normal foveas. Distributions of cone and RPE cell densities were fitted with nonlinear mixed-effects models. A linear mixed-effects model was used to examine the relationship between cone and RPE inter-cell distances and foveal shape as obtained from the OCT scans of retinal thickness.</p><p>Results: The best-fit model to the cone densities was a power function with a nasal–temporal asymmetry. There was a significant linear relationship among cone and RPE cell spacing, foveal shape, and foveal cell topography. The model predictions of the central 10° show that the contributions of both the cones and RPE cells are necessary to account for foveal shape.</p><p>Conclusions: The results indicate that there is a strong relationship between cone and RPE cell spacing and the shape of the human adolescent and adult fovea. This finding adds to the existing evidence of the critical role that the RPE serves in fetal foveal development and through adolescence, possibly via the imposition of constraints on the number and distribution of foveal cones.</p></div><div></div> |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Notes: |
<a href="http://creativecommons.org/licenses/by/4.0">CC BY 4.0</a> |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Title: |
Baraas RC, Pedersen HR, Knoblauch K, Gilson SJ. Human Foveal Cone and RPE Cell Topographies and Their Correspondence With Foveal Shape. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):8. doi: 10.1167/iovs.63.2.8 |
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Identification Number: |
10.1167/iovs.63.2.8 |
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Bibliographic Citation: |
Baraas RC, Pedersen HR, Knoblauch K, Gilson SJ. Human Foveal Cone and RPE Cell Topographies and Their Correspondence With Foveal Shape. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):8. doi: 10.1167/iovs.63.2.8 |
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Label: |
Foveal_density.csv |
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Text: |
Foveal_density.csv |
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Notes: |
text/csv |
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Label: |
ReadMe_Foveal_conedensity.txt |
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Text: |
ReadMe_Foveal_conedensity.txt |
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Notes: |
text/plain |