10.18710/1IHNDDMelum, VebjørnVebjørnMelumUiT The Arctic University of NorwaySaenz de Miera, CristinaCristinaSaenz de MieraUniversity of MichiganMarkussen, FredrikFredrikMarkussenUiT The Arctic University of NorwayJaeger, CatherineCatherineJaegerUniversity of StrasbourgCázarez-Márquez, FernandoFernandoCázarez-Márquez0000-0002-7840-2048UiT The Arctic University of NorwayUiT The Arctic University of NorwaySandve, SimenSimenSandve0000-0003-4989-5311Norwegian University of Life SciencesSimonneaux, ValerieValerieSimonneauxUniversity of StrasbourgHazlerigg, DavidDavidHazlerigg0000-0003-4884-8409UiT The Arctic University of NorwayWood, ShonaShonaWood0000-0002-8273-4045UiT The Arctic University of NorwayDataverseNO2023OtherBiologyChronobiologyTanycyteMaternal programmingWood, ShonaShonaWoodUiT The Arctic University of NorwayUiT The Arctic University of NorwayGrønvold, LarsLarsGrønvoldTo, Thu-HienThu-HienToUiT The Arctic University of NorwayUiT The Arctic University of Norway2023-12-062023-12-142020-01-01/2023-03-20Experimental data10.1016/j.cub.2023.12.042.2199840646637102022592950text/plaintext/plaintext/plaintext/tsvtext/plain1.0CC0 1.0The following data is provided to support the publication: "Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity". The data provided are body and testis weight for phodopus sungorus raised on different photoperiods, the genome assembly statistics for Phodopus sungorus, a comparative analysis of genes present in tanycytes LASER captured from animals gestated and raised on different photoperiods with genes and clusters defined in a pseduotime analysis of tanycytes in mice. Finally we provide counts of JASPAR motifs occuring across the Phodopus sungorus genome.Abstract from publication: In mammals, maternal photoperiodic programming (MPP) provides a means whereby juvenile development can be matched to forthcoming seasonal environmental conditions. This phenomenon is driven by in utero effects of maternal melatonin on the production of thyrotropin (TSH) in the fetal pars tuberalis (PT) and consequent TSH receptor-mediated effects on tanycytes lining the 3rd ventricle of the mediobasal hypothalamus (MBH). Here we use LASER capture microdissection and transcriptomic profiling to show that TSH-dependent MPP controls the attributes of the ependymal region of the MBH in juvenile animals. In Siberian hamster pups gestated and raised on a long photoperiod (LP) and thereby committed to a fast trajectory for growth and reproductive maturation, the ependymal region is enriched for tanycytes bearing sensory cilia and receptors implicated in metabolic sensing. Contrastingly, in pups gestated and raised on short photoperiod (SP) and therefore following an overwintering developmental trajectory with delayed sexual maturation, the ependymal region has fewer sensory tanycytes. Post-weaning transfer of SP-gestated pups to an intermediate photoperiod (IP), which accelerates reproductive maturation, results in a pronounced shift towards a ciliated tanycytic profile and formation of tanycytic processes. We suggest that tanycytic plasticity constitutes a mechanism to tailor metabolic development for extended survival in variable overwintering environments.R, V3.4Tromsø Research FoundationTFS2016SWTromsø Research FoundationIS3_17_SWThe Research Council of NorwayOverseas research grantFonds Paul Mandel pour les recherches en neurosciencesepigenetic calendarsUniversity of Strasbourg Institute 212 for Advanced Studies fellowshipepigenetic lightUiT The Arctic University of NorwayArctic 213 seasonal timekeeping initiative (ASTI)