Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties

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Langer, Manuel Karl; Bayer, Annette, 2022, "Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties", https://doi.org/10.18710/A6AJN4, DataverseNO, V1

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Description	This dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files. All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files. (2022-11-14)
Subject	Chemistry; Medicine, Health and Life Sciences
Keyword	Antimicrobial peptides, AMPs, Amphipathic, Tetrasubstituted Barbiturates, Small mimics of antimicrobial peptides, SMAMPs, Nuclear magnetic resonance, NMR, High resolution mass spectrometry, HRMS, Infrafred spectroscopy, IR, Supercritical fluid chromatography, SFC
Related Publication	Manuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Hans-Matti Blencke, Tor Haug, Klara Stensvåg, Morten B. Strøm, Annette Bayer, Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties, Eur. J. Med. Chem., 249 (2023) 115147. doi: 10.1016/j.ejmech.2023.115147
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Citation Metadata

Persistent Identifier	doi:10.18710/A6AJN4
Publication Date	2022-11-17
Title	Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties
Author	Langer, Manuel Karl (UiT The Arctic University of Norway) - ORCID: 0000-0002-6174-7381 Bayer, Annette (UiT The Arctic University of Norway) - ORCID: 0000-0003-3481-200X
Point of Contact	Use email button above to contact. Langer, Manuel Karl (UiT The Arctic University of Norway)
Description	This dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files. All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files. (2022-11-14)
Subject	Chemistry; Medicine, Health and Life Sciences
Keyword	Antimicrobial peptides AMPs Amphipathic, Tetrasubstituted Barbiturates Small mimics of antimicrobial peptides SMAMPs Nuclear magnetic resonance NMR High resolution mass spectrometry HRMS Infrafred spectroscopy IR Supercritical fluid chromatography SFC
Related Publication	Manuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Hans-Matti Blencke, Tor Haug, Klara Stensvåg, Morten B. Strøm, Annette Bayer, Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties, Eur. J. Med. Chem., 249 (2023) 115147. doi: 10.1016/j.ejmech.2023.115147 https://doi.org/10.1016/j.ejmech.2023.115147
Language	English
Producer	UiT The Arctic University of Norway (UiT) https://en.uit.no/
Production Date	2022-05-22
Production Location	Tromsø
Contributor	Data Collector : Langer, Manuel Karl Researcher : Johansen, Jostein Supervisor : Bayer, Annette
Funding Information	UiT The Arctic University of Norway UiT The Arctic University of Norway: 2017/6770
Distributor	UiT The Arctic University of Norway (UiT The Arctic University of Norway) https://dataverse.no/dataverse/uit
Depositor	Langer, Manuel K
Deposit Date	2022-11-14
Date of Collection	Start Date: 2018-07-20 ; End Date: 2022-04-04
Data Type	Analytical data
Software	MassLynx, Version: V4.1 LTQ Tune Plus, Version: V2.5.5 SP2 Qual Browser Thermo Xcalibur, Version: 2.1.0 SP1.1160 Icon NMR for TopSpin 3.2, Version: 4.7.6 Build 22 Thermo Scientific SII for Xcalibur, Version: 1.6.060983 Thermo Scientific FreeStyle, Version: 1.8 SP2 Thermo Scientific Xcalibur, Version: 4.4.16.14

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