Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties

Version 1.1

Langer, Manuel Karl; Bayer, Annette, 2022, "Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties", https://doi.org/10.18710/A6AJN4, DataverseNO, V1

Learn about Data Citation Standards.

Contact Owner

Dataset Metrics

11 Downloads

Description	This dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files. All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files. (2022-11-14)
Subject	Chemistry; Medicine, Health and Life Sciences
Keyword	Antimicrobial peptides, AMPs, Amphipathic, Tetrasubstituted Barbiturates, Small mimics of antimicrobial peptides, SMAMPs, Nuclear magnetic resonance, NMR, High resolution mass spectrometry, HRMS, Infrafred spectroscopy, IR, Supercritical fluid chromatography, SFC
Related Publication	Submitted manuscript
License/Data Use Agreement	CC0 1.0

Filter by

	1 to 7 of 7 Files	Download
	00_README_edit.txt Plain Text - 14.0 KB Published Nov 17, 2022 2 Downloads MD5: 920cf4f6f47c692c867e1b947c855811	Preview "00_README_edit.txt" Access File File Access Public Download Options Plain Text Download Metadata Data File Citation EndNote XML RIS BibTeX
	01_Chemical_structures.pdf Adobe PDF - 476.8 KB Published Nov 17, 2022 2 Downloads MD5: 05712c12855137a607e92c90ba49dc8a	Preview "01_Chemical_structures.pdf" Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX
	02_Analytical_data_overview.pdf Adobe PDF - 118.7 KB Published Nov 17, 2022 3 Downloads MD5: 7e36ed3c45b88b0089731978d67ead16	Preview "02_Analytical_data_overview.pdf" Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX
	03_Analytical_data_overview.csv Comma Separated Values - 1.8 KB Published Nov 17, 2022 1 Download MD5: ede947c29ba5e9e89c1f34b9f574db08	Preview "03_Analytical_data_overview.csv" Access File File Access Public Download Options Comma Separated Values Download Metadata Data File Citation EndNote XML RIS BibTeX
	04_SMILEs_all_structures.csv Comma Separated Values - 4.1 KB Published Nov 17, 2022 1 Download MD5: 7353c80fe734d876a94b84463dc6a266	Preview "04_SMILEs_all_structures.csv" Access File File Access Public Download Options Comma Separated Values Download Metadata Data File Citation EndNote XML RIS BibTeX
	05_file_tree.txt Plain Text - 93.6 KB Published Nov 17, 2022 1 Download MD5: f6044a05b889e1920277d3f6e2b108e2	Preview "05_file_tree.txt" Access File File Access Public Download Options Plain Text Download Metadata Data File Citation EndNote XML RIS BibTeX
	raw_data.zip ZIP Archive - 66.6 MB Published Nov 17, 2022 1 Download MD5: 5d038e291cd8306877c9177978c0f07c	Access File File Access Public Download Options ZIP Archive Download Metadata Data File Citation EndNote XML RIS BibTeX

Citation Metadata

Persistent Identifier	doi:10.18710/A6AJN4
Publication Date	2022-11-17
Title	Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties
Author	Langer, Manuel Karl (UiT The Arctic University of Norway) - ORCID: 0000-0002-6174-7381 Bayer, Annette (UiT The Arctic University of Norway) - ORCID: 0000-0003-3481-200X
Point of Contact	Use email button above to contact. Langer, Manuel Karl (UiT The Arctic University of Norway)
Description	This dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files. All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files. (2022-11-14)
Subject	Chemistry; Medicine, Health and Life Sciences
Keyword	Antimicrobial peptides AMPs Amphipathic, Tetrasubstituted Barbiturates Small mimics of antimicrobial peptides SMAMPs Nuclear magnetic resonance NMR High resolution mass spectrometry HRMS Infrafred spectroscopy IR Supercritical fluid chromatography SFC
Related Publication	Submitted manuscript
Language	English
Producer	UiT The Arctic University of Norway (UiT) https://en.uit.no/
Production Date	2022-05-22
Production Location	Tromsø
Contributor	Data Collector : Langer, Manuel Karl Researcher : Johansen, Jostein Supervisor : Bayer, Annette
Funding Information	UiT The Arctic University of Norway UiT The Arctic University of Norway: 2017/6770
Distributor	UiT The Arctic University of Norway (UiT The Arctic University of Norway) https://dataverse.no/dataverse/uit
Depositor	Langer, Manuel K
Deposit Date	2022-11-14
Date of Collection	Start Date: 2018-07-20 ; End Date: 2022-04-04
Data Type	Analytical data
Software	MassLynx, Version: V4.1 LTQ Tune Plus, Version: V2.5.5 SP2 Qual Browser Thermo Xcalibur, Version: 2.1.0 SP1.1160 Icon NMR for TopSpin 3.2, Version: 4.7.6 Build 22 Thermo Scientific SII for Xcalibur, Version: 1.6.060983 Thermo Scientific FreeStyle, Version: 1.8 SP2 Thermo Scientific Xcalibur, Version: 4.4.16.14

Dataset Terms

License/Data Use Agreement

Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.

Creative Commons CC0 1.0 Universal Public Domain Dedication. CC0 1.0

Dataset Version	Summary	Contributors	Published on
No records found.

Edit File

This file has already been deleted (or replaced) in the current version. It may not be edited.

Restrict Access

Restricting limits access to published files. People who want to use the restricted files can request access by default. If you disable request access, you must add information about access to the Terms of Access field.

Learn about restricting files and dataset access in the User Guide.

Request Access

Enable access request

You must enable request access or add terms of access to restrict file access.

Terms of Access for Restricted Files

Save Changes

Edit Embargo

The selected file or files have already been published. Contact an administrator to change the embargo date or reason of the file or files.

Delete Files

The file will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Select File(s)

Please select one or more files.

Share Dataset

Share this dataset on your favorite social media networks.

Dataset Citations

Citations for this dataset are retrieved from Crossref via DataCite using Make Data Count standards. For more information about dataset metrics, please refer to the User Guide.

Sorry, no citations were found.

Restricted Files Selected

The selected file(s) may not be downloaded because you have not been granted access.

You may request access to the restricted file(s) by clicking the Request Access button.

Download Options

The files selected are too large to download as a ZIP.

You can select individual files that are below the 100.0 MB download limit from the files table, or use the Data Access API for programmatic access to the files.

Select File(s)

Please select a file or files to be downloaded.

Restricted Files Selected

The restricted file(s) selected may not be downloaded because you have not been granted access.

Click Continue to download the files you have access to download.

Delete Dataset

Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.

Delete Draft Version

Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.

Unpublished Dataset Private URL

Private URL can only be used with unpublished versions of datasets.

Unpublished Dataset Private URL

Are you sure you want to disable the Private URL? If you have shared the Private URL with others they will no longer be able to use it to access your unpublished dataset.

Delete Files

The file(s) will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Compute

This dataset contains restricted files you may not compute on because you have not been granted access.

Deaccession Dataset

Are you sure you want to deaccession? The selected version(s) will no longer be viewable by the public.

Deaccession Dataset

Are you sure you want to deaccession this dataset? It will no longer be viewable by the public.

Version Differences Details

Please select two versions to view the differences.

Version Differences Details

Version:
Last Updated:

Select File(s)

Please select a file or files for access request.

Select File(s)

Embargoed files cannot be accessed. Please select an unembargoed file or files for your access request.

Edit Tags

Select existing file tags or create new tags to describe your files. Each file can have more than one tag.

Request Access

You need to Log In to request access.

Dataset Terms

This dataset is made available under the following terms. Please confirm and/or complete the information needed below in order to continue.

License/Data Use Agreement

Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.

Creative Commons CC0 1.0 Universal Public Domain Dedication. CC0 1.0

Preview Guestbook

Upon downloading files the guestbook asks for the following information.

Guestbook Name

Collected Data

Account Information

Package File Download

Use the Download URL in a Wget command or a download manager to download this package file. Download via web browser is not recommended. User Guide - Downloading a Dataverse Package via URL

Download URL

https://dataverse.no/api/access/datafile/

Request Access

Please confirm and/or complete the information needed below in order to request access to files in this dataset.

Compute Batch

Clear Batch

Dataset	Persistent Identifier	Change Compute Batch

Compute Batch

Submit for Review

You will not be able to make changes to this dataset while it is in review.

Publish Dataset

Are you sure you want to republish this dataset?

Select if this is a minor or major version update.

Minor Release (1.2)

Major Release (2.0)

Publish Dataset

This dataset cannot be published until UiT The Arctic University of Norway is published by its administrator.

Publish Dataset

This dataset cannot be published until UiT The Arctic University of Norway and DataverseNO are published.

Return to Author

Return this dataset to contributor for modification.