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MD5: a9e8264fc5b06ccdd127dc08940de760
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R Syntax - 21.3 KB -
MD5: e95685d8053ff604db4e38212f77e1c9
R script for performing curve fitting, FPCA, and generate plots of postprandial curves |
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MD5: 151791bb0eea3a612f729c963c1f9e04
RMarkdown file as .pdf containing the imputation procedure used for the missing postprandial data |
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MD5: 01331e81efc1de68d50703903d7ca590
Supplementary figure S1: Curve fitting with different degrees of smoothing. The plots (A-C) shows the 0-120 min postprandial data from 10 randomly selected participants, together with their respective smoothed postprandial curve. Each subplot shows smoothing with a specific value of teh smoothing parameter, lambda, as indicated in the plot title. T... |
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MD5: 7967fc349f6e7d17c8e6c462ff6668f0
Supplementary figure. S2: Plots of all smooth postprandial curves.
The 16 separate plots show the estimated postprandial curves based on fasting and postprandial measurements of, respectively, alanine aminotransferase, albumin, alkaline phosphatase, bilirubin, C-reactive protein, free thyroxine, glucose, gamma-glutamyl transferase, High-density... |
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MD5: 00476f82bc8b73f7e76ed317fd286af3
Supplementary Fig. S3: FPCA of all postprandial variables.
The 32 sets of plots (one set of plots at each page) show the results from functional principal component analyses (FPCA) of the postprandial curves of the 15 postprandial variables, and incremental triacylglycerol.
Both the FPCA of the 0-120 minute interval and the 0-240 interval is pre... |
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MD5: 8c26e4642e0f55aea074883567935de4
Supplementary Fig. S4: Plots of FPC curves, harmonics.
The plots show the three first functional principal component curves (FPCs, harmonics) for glucose, C-peptide, TAGs, and incremental TAGs, respectively.
In all plots, the black, solid line represents the first FPC, the red dashed line represents the second FPC, and the green dotted line repr... |
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MD5: 1c59a3c4d117ff1f76e6b89fe61a8762
Supplementary Fig. S5: Correlation matrix.
The figure shows a Pearson correlation matrix including FPC score variables, as well as a large number of various summary measures of glucose, C-peptide and triacylglycerol, as well as insulin resistance.
Correlation direction is indicated by text color (red = positive, blue = negative), and transparenc... |
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MD5: 49b3919645f3f6ffd281dcb1c9f6100b
Supplementary Fig. S6: FPCA stratified by sex.
Plots A1 – A3, B1 – B3, C1 – C3 and D1 – D3 show the results from FPCAs of glucose, C-peptide, triacylglycerol and incremental triacylglycerol, respectively - not stratified by sex.
All single plots display the entire set of n=190 individual curves but coloured according to the scores of a specified... |
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MD5: d001c305bdd00ce37974473794a98102
Supplementary Fig. S7: Heatmap, original.
The heatmap shows the Pearson correlations between the FPC score variables for glucose, C-peptide, and TAG to a range of metabolic features including circulating fasting metabolite concentrations and body composition.
Blue cells in the heatmap indicate strong positive correlation between variables, and y... |
